Antibiotic-Receptor Molecular Interactions

Molecular Insight into the Mutual Interactions of Two Transmembrane Domains of Human Glycine Receptor (TM23-GlyR), with the Lipid Bilayers

Appearing as a computational microscope, MD simulation can ‘zoom in’ to atomic resolution to assess detailed interactions of a membrane protein with its surrounding lipids, which play important roles in the stability and function of such proteins. This study has employed the molecular dynamics (MD) simulations, to determine the effect of added DMPC or DMTAP molecules on the structure of D...

Molecular Mechanisms of Androgen Receptor Interactions

Finland ACADEMIC DISSERTATION To be publicly discussed with the permission of

Molecular Interactions in the Norrin Receptor Complex

Artificial Neural Networks Analysis Used to Evaluate the Molecular Interactions between Selected Drugs and Human Cyclooxygenase2 Receptor

  Objective(s): A fast and reliable evaluation of the binding energy from a single conformation of a molecular complex is an important practical task. Artificial neural networks (ANNs) are strong tools for predicting nonlinear functions which are used in this paper to predict binding energy. We proposed a structure that obtains binding energy using physicochemical molecular descripti...

Drug Antibiotic Interactions-antimalarials

The antimicrobial effects of four antimalarials were determined. The effect of the chosen drugs when combined with a selected number of antibiotics was studied on Staphylococcus aureus and Escherichia coli to determine the types of interaction. Most antimalarials showed either no effect or a synergistic action. However, some exhibited antagonistic effects, which may be either due to some physic...